| Date | À domicile | A l'extérieur | Résultat |
|---|---|---|---|
| 04/12/21 22:00 | Deportes La Serena | Santiago Wanderers | 0-0 |
| 04/12/21 22:00 | Everton | Universidad Católica | 0-3 |
| 04/12/21 22:00 | Palestino | Ñublense | 1-4 |
| 04/12/21 22:00 | CD Antofagasta | Colo-Colo | 1-0 |
| 05/12/21 22:00 | Unión Española | Cobresal | 0-1 |
| 05/12/21 22:00 | Huachipato | Deportes Melipilla | 3-1 |
| 05/12/21 22:00 | Audax Italiano | Curico Unido | 1-1 |
| 05/12/21 22:00 | Universidad de Chili | Unión La Calera | 3-2 |