| Date | À domicile | A l'extérieur | Résultat |
|---|---|---|---|
| 10/12/21 01:30 | Sport Recife | Athletico Paranaense | 1-1 |
| 10/12/21 01:30 | Red Bull Bragantino | Internacional | 1-0 |
| 10/12/21 01:30 | Gremio Porto Alegre | Club Atletico Mineiro | 4-3 |
| 10/12/21 01:30 | FC Santos | Cuiaba EC | 1-1 |
| 10/12/21 01:30 | Fluminense | AF Chapecoense | 3-0 |
| 10/12/21 01:30 | EC Juventude | Corinthians | 1-0 |
| 10/12/21 01:30 | America FC | FC Sao Paulo | 2-0 |
| 10/12/21 01:30 | Fortaleza | Bahia BA | 2-1 |
| 10/12/21 01:30 | Palmeiras | Ceará | 1-0 |
| 10/12/21 01:30 | Atletico Goianiense | Flamengo | 2-0 |