| Date | À domicile | A l'extérieur | Résultat |
|---|---|---|---|
| 23/09/25 17:00 | Cagliari Calcio | Frosinone Calcio | 4-1 |
| 23/09/25 18:30 | Udinese Calcio | Palermo FC | 2-1 |
| 23/09/25 21:00 | AC Milan | US Lecce | 3-0 |
| 24/09/25 17:00 | Parma Calcio 1913 | Spezia Calcio | 6-5a.TAB/2-290m |
| 24/09/25 18:30 | Hellas Verona | FC Venise | 4-5a.TAB/0-090m |
| 24/09/25 21:00 | Como Calcio | Sassuolo Calcio | 3-0 |
| 25/09/25 18:30 | Genua CFC | FC Empoli | 3-1 |
| 25/09/25 21:00 | FC Turin | Pisa Sporting Club | 1-0 |
| 30/09/25 20:30 | Palermo FC | FC Venise | 0-0 |
| 30/09/25 20:30 | Juve Stabia | Mantova 1911 | 2-1 |
| 30/09/25 20:30 | Padova Calcio | US Avellino | 2-2 |
| 30/09/25 20:30 | AC Reggiana 1919 | Spezia Calcio | 1-1 |
| 30/09/25 20:30 | Virtus Entella | SSC Bari | 2-2 |
| 30/09/25 20:30 | Frosinone Calcio | FC Cesena | 3-1 |
| 01/10/25 20:30 | Pescara Calcio | FC Tirol du Sud | 1-1 |
| 01/10/25 20:30 | Sampdoria Genua | US Catanzaro 1929 | 0-0 |
| 01/10/25 20:30 | Carrarese Calcio 1908 | Modena FC | 0-0 |
| 01/10/25 20:30 | FC Empoli | AC Monza | 1-1 |
| 03/10/25 20:45 | Hellas Verona | Sassuolo Calcio | 0-1 |
| 04/10/25 15:00 | Lazio Rom | FC Turin | 3-3 |
| 04/10/25 15:00 | Parma Calcio 1913 | US Lecce | 0-1 |
| 04/10/25 18:00 | Inter Milan | US Cremonese | 4-1 |
| 04/10/25 20:45 | Atalanta Bergamo | Como Calcio | 1-1 |
| 05/10/25 12:30 | Udinese Calcio | Cagliari Calcio | 1-1 |
| 05/10/25 15:00 | FC Bologna | Pisa Sporting Club | 4-0 |
| 05/10/25 15:00 | AC Florenz | AS Rome | 1-2 |
| 05/10/25 18:00 | SSC Naples | Genua CFC | 2-1 |
| 05/10/25 20:45 | Juventus Turin | AC Milan | 0-0 |