| Date | Clôture des pronostics | À domicile | A l'extérieur | Résultat | Règle des points |
|---|
| 11/09/21 15:30 | 11/09/21 15:00 | SpVgg Greuther Fürth | VfL Wolfsburg | 0-2 | 2 - 4 points |
| 11/09/21 15:30 | 11/09/21 15:00 | 1899 Hoffenheim | FSV Mayence 05 | 0-2 | 2 - 4 points |
| 11/09/21 15:30 | 11/09/21 15:00 | SC Freiburg | 1. FC Cologne | 1-1 | 2 - 4 points |
| 11/09/21 15:30 | 11/09/21 15:00 | 1. FC Union Berlin | FC Augsburg | 0-0 | 2 - 4 points |
| 11/09/21 15:30 | 11/09/21 15:00 | Bayer 04 Leverkusen | Borussia Dortmund | 3-4 | 2 - 4 points |
| 11/09/21 18:30 | 11/09/21 18:00 | RB Leipzig | Bayern Munich | 1-4 | 2 - 4 points |
| 12/09/21 15:30 | 12/09/21 15:00 | Eintracht Frankfurt | VfB Stuttgart | 1-1 | 2 - 4 points |
| 12/09/21 17:30 | 12/09/21 17:00 | VfL Bochum | Hertha BSC | 1-3 | 2 - 4 points |
| 12/09/21 19:30 | 12/09/21 19:00 | Bor. Mönchengladbach | Arminia Bielefeld | 3-1 | 2 - 4 points |
