Calendrier
| Date | Clôture des pronostics | À domicile | A l'extérieur | Résultat | Règle des points |
|---|---|---|---|---|---|
| 03/12/21 21:00 | 03/12/21 21:00 | US Quevilly Rouen | AS Nancy-Lorraine | 2-1 | 5 - 7 points |
| 03/12/21 21:00 | 03/12/21 21:00 | Rodez Aveyron | Nîmes Olympique | 1-0 | 5 - 7 points |
| 03/12/21 21:00 | 03/12/21 21:00 | FC Sochaux-Montbéliard | Pau FC | 2-1 | 5 - 7 points |
| 03/12/21 21:00 | 03/12/21 21:00 | Paris FC | SC Bastia | 1-0 | 5 - 7 points |
| 03/12/21 21:00 | 03/12/21 21:00 | AC Ajaccio | Valenciennes FC | 0-0 | 5 - 7 points |
| 03/12/21 21:00 | 03/12/21 21:00 | Amiens SC | USL Dunkerque | 3-0 | 5 - 7 points |
| 03/12/21 21:00 | 03/12/21 21:00 | Grenoble Foot | Havre AC | 1-2 | 5 - 7 points |
| 03/12/21 21:00 | 03/12/21 21:00 | En Avant Guingamp | Dijon FCO | 3-2 | 5 - 7 points |
| 04/12/21 15:00 | 04/12/21 15:00 | AJ Auxerre | Stade Malherbe Caen | 2-2 | 5 - 7 points |
| 06/12/21 20:45 | 06/12/21 20:45 | Chamois Niortais FC | Toulouse FC | 2-1 | 5 - 7 points |