Calendrier
| Date | Clôture des pronostics | À domicile | A l'extérieur | Résultat | Règle des points |
|---|---|---|---|---|---|
| 24/09/21 21:00 | 24/09/21 21:00 | Rodez Aveyron | Grenoble Foot | 1-1 | 5 - 7 points |
| 24/09/21 21:00 | 24/09/21 21:00 | FC Sochaux-Montbéliard | AJ Auxerre | 0-0 | 5 - 7 points |
| 24/09/21 21:00 | 24/09/21 21:00 | Dijon FCO | Valenciennes FC | 0-1 | 5 - 7 points |
| 24/09/21 21:00 | 24/09/21 21:00 | AS Nancy-Lorraine | Amiens SC | 1-1 | 5 - 7 points |
| 24/09/21 21:00 | 24/09/21 21:00 | Nîmes Olympique | Havre AC | 0-1 | 5 - 7 points |
| 24/09/21 21:00 | 24/09/21 21:00 | Chamois Niortais FC | Paris FC | 4-1 | 5 - 7 points |
| 24/09/21 21:00 | 24/09/21 21:00 | Pau FC | USL Dunkerque | 1-2 | 5 - 7 points |
| 24/09/21 21:00 | 24/09/21 21:00 | US Quevilly Rouen | En Avant Guingamp | 2-2 | 5 - 7 points |
| 25/09/21 15:00 | 25/09/21 15:00 | SC Bastia | AC Ajaccio | 2-0 | 5 - 7 points |
| 27/09/21 20:45 | 27/09/21 20:45 | Toulouse FC | Stade Malherbe Caen | 2-3 | 5 - 7 points |