Calendrier
| Date | Clôture des pronostics | À domicile | A l'extérieur | Résultat | Règle des points |
|---|---|---|---|---|---|
| 05/11/21 21:00 | 05/11/21 21:00 | RC Lens | ES Troyes AC | 4-0 | 5 - 7 points |
| 06/11/21 17:00 | 06/11/21 17:00 | LOSC Lille | Angers SCO | 1-1 | 5 - 7 points |
| 06/11/21 21:00 | 06/11/21 21:00 | Girondins de Bordeaux | Paris Saint-Germain | 2-3 | 5 - 7 points |
| 07/11/21 13:00 | 07/11/21 13:00 | Olympique de Marseille | FC Metz | 0-0 | 5 - 7 points |
| 07/11/21 15:00 | 07/11/21 15:00 | FC Lorient | Stade Brestois 29 | 1-2 | 5 - 7 points |
| 07/11/21 15:00 | 07/11/21 15:00 | FC Nantes | Racing Club Strasbourg | 2-2 | 5 - 7 points |
| 07/11/21 15:00 | 07/11/21 15:00 | Stade de Reims | AS Monaco | 0-0 | 5 - 7 points |
| 07/11/21 15:00 | 07/11/21 15:00 | AS St. Etienne | Clermont Foot | 3-2 | 5 - 7 points |
| 07/11/21 17:05 | 07/11/21 17:05 | OGC Nice | Montpellier Hérault SC | 0-1 | 5 - 7 points |
| 07/11/21 20:45 | 07/11/21 20:45 | Stade Rennais FC | Olympique Lyonnais | 4-1 | 5 - 7 points |