Calendrier
| Date | Clôture des pronostics | À domicile | A l'extérieur | Résultat | Règle des points |
|---|---|---|---|---|---|
| 24/09/21 20:45 | 24/09/21 20:45 | FC Bruges | OH Leuven | 1-1 | 5 - 7 points |
| 25/09/21 16:15 | 25/09/21 16:15 | K. Beerschot V.A. | KAS Eupen | 0-3 | 5 - 7 points |
| 25/09/21 18:30 | 25/09/21 18:30 | SV Zulte-Waregem | KV Kortrijk | 2-2 | 5 - 7 points |
| 25/09/21 20:45 | 25/09/21 20:45 | Standard Liège | Sint-Truidense VV | 1-2 | 5 - 7 points |
| 26/09/21 13:30 | 26/09/21 13:30 | Royale Union Saint-Gilloise | Royal Antwerp FC | 1-2 | 5 - 7 points |
| 26/09/21 16:00 | 26/09/21 16:00 | La Gantoise | KSV Cercle Brügge | 2-1 | 5 - 7 points |
| 26/09/21 18:30 | 26/09/21 18:30 | KV Oostende | RSC Anderlecht | 2-2 | 5 - 7 points |
| 26/09/21 21:00 | 26/09/21 21:00 | KRC Genk | RFC Seraing | 3-0 | 5 - 7 points |
| 26/09/21 21:00 | 26/09/21 21:00 | Sporting Charleroi | FC Malinois | 0-2 | 5 - 7 points |