Calendrier
| Date | Clôture des pronostics | À domicile | A l'extérieur | Résultat | Règle des points |
|---|---|---|---|---|---|
| 17/09/21 20:45 | 17/09/21 20:45 | KSV Cercle Brügge | KAS Eupen | 1-2 | 5 - 7 points |
| 18/09/21 16:15 | 18/09/21 16:15 | KV Oostende | K. Beerschot V.A. | 3-1 | 5 - 7 points |
| 18/09/21 18:30 | 18/09/21 18:30 | Royale Union Saint-Gilloise | SV Zulte-Waregem | 2-1 | 5 - 7 points |
| 18/09/21 18:30 | 18/09/21 18:30 | FC Malinois | OH Leuven | 2-0 | 5 - 7 points |
| 18/09/21 20:45 | 18/09/21 20:45 | Sporting Charleroi | FC Bruges | 0-1 | 5 - 7 points |
| 19/09/21 13:30 | 19/09/21 13:30 | Sint-Truidense VV | KRC Genk | 1-2 | 5 - 7 points |
| 19/09/21 16:00 | 19/09/21 16:00 | Royal Antwerp FC | RFC Seraing | 2-1 | 5 - 7 points |
| 19/09/21 18:30 | 19/09/21 18:30 | Standard Liège | RSC Anderlecht | 0-1 | 5 - 7 points |
| 19/09/21 21:00 | 19/09/21 21:00 | KV Kortrijk | La Gantoise | 1-0 | 5 - 7 points |