Calendrier
| Date | Clôture des pronostics | À domicile | A l'extérieur | Résultat | Règle des points |
|---|---|---|---|---|---|
| 10/09/21 20:45 | 10/09/21 20:45 | FC Bruges | KV Oostende | 3-0 | 5 - 7 points |
| 11/09/21 16:15 | 11/09/21 16:15 | KAS Eupen | Royal Antwerp FC | 0-1 | 5 - 7 points |
| 11/09/21 18:30 | 11/09/21 18:30 | SV Zulte-Waregem | KSV Cercle Brügge | 2-4 | 5 - 7 points |
| 12/09/21 13:30 | 12/09/21 13:30 | RSC Anderlecht | FC Malinois | 7-2 | 5 - 7 points |
| 12/09/21 16:00 | 12/09/21 16:00 | La Gantoise | Sporting Charleroi | 2-3 | 5 - 7 points |
| 12/09/21 18:30 | 12/09/21 18:30 | RFC Seraing | Standard Liège | 0-1 | 5 - 7 points |
| 12/09/21 21:00 | 12/09/21 21:00 | KRC Genk | Royale Union Saint-Gilloise | 1-1 | 5 - 7 points |
| 12/09/21 21:00 | 12/09/21 21:00 | OH Leuven | KV Kortrijk | 2-1 | 5 - 7 points |
| 13/09/21 20:00 | 13/09/21 20:00 | K. Beerschot V.A. | Sint-Truidense VV | 0-1 | 5 - 7 points |