Calendrier
| Compétition | Date | Clôture des pronostics | À domicile | A l'extérieur | Résultat | Règle des points |
|---|---|---|---|---|---|---|
| CDR | 14/12/21 19:00 | 14/12/21 19:00 | Andorre CF | Celta Vigo | 1-2a.Prlg | 2 - 4 points |
| CDR | 14/12/21 19:00 | 14/12/21 19:00 | San Sebastian de los Reyes | CF Fuenlabrada | 4-5a.TAB | 2 - 4 points |
| CDR | 14/12/21 20:00 | 14/12/21 20:00 | SD Huesca | FC Girona | 0-1 | 2 - 4 points |
| CDR | 14/12/21 20:00 | 14/12/21 20:00 | CF Rayo Majadahonda | FC Malaga | 1-0 | 2 - 4 points |
| CDR | 14/12/21 20:00 | 14/12/21 20:00 | Real Saragosse | Burgos CF | 2-0 | 2 - 4 points |
| CDR | 14/12/21 21:00 | 14/12/21 21:00 | CD Alcoyano | UD Levante | 6-4a.TAB | 2 - 4 points |
| CDR | 14/12/21 21:00 | 14/12/21 21:00 | Linares Deportivo | Deportivo Alaves | 2-1 | 2 - 4 points |
| CDR | 14/12/21 21:00 | 14/12/21 21:00 | CF Cristo Atletico | Espanyol Barcelone | 1-2 | 2 - 4 points |
| CDR | 15/12/21 19:00 | 15/12/21 19:00 | Bergantinos CF | Rayo Vallecano | 1-3 | 2 - 4 points |
| CDR | 15/12/21 19:00 | 15/12/21 19:00 | Zamora CF | Real Sociedad | 0-3 | 2 - 4 points |
| CDR | 15/12/21 19:00 | 15/12/21 19:00 | CE Andratx | FC Séville | 6-7a.TAB | 2 - 4 points |
| CDR | 15/12/21 19:30 | 15/12/21 19:30 | Cultural y Deportiva Leonesa | CD Leganes | 2-3a.Prlg | 2 - 4 points |
| CDR | 15/12/21 20:00 | 15/12/21 20:00 | CD Castellon | FC Cartagena | 1-2 | 2 - 4 points |
| CDR | 15/12/21 20:00 | 15/12/21 20:00 | Sporting Gijon | AD Alcorcon | 2-1a.Prlg | 2 - 4 points |
| CDR | 15/12/21 20:00 | 15/12/21 20:00 | SD Ponferradina | UD Ibiza Eivissa | 2-1a.Prlg | 2 - 4 points |
| CDR | 15/12/21 20:00 | 15/12/21 20:00 | Real Valladolid | UD Las Palmas | 3-1 | 2 - 4 points |
| CDR | 15/12/21 21:00 | 15/12/21 21:00 | CD Tenerife | SD Eibar | 1-2 | 2 - 4 points |
| CDR | 15/12/21 21:00 | 15/12/21 21:00 | Unionistas de Salamanca | FC Elche | 0-1 | 2 - 4 points |
| CDR | 15/12/21 21:00 | 15/12/21 21:00 | Atletico Sanluqueno CF | Villarreal CF | 1-7 | 2 - 4 points |
| CDR | 16/12/21 19:00 | 16/12/21 19:00 | UD Llanera | RCD Majorque | 0-6 | 2 - 4 points |
| CDR | 16/12/21 19:00 | 16/12/21 19:00 | SD Amorebieta | UD Almeria | 1-2 | 2 - 4 points |
| CDR | 16/12/21 19:00 | 16/12/21 19:00 | CF Talavera de la Reina | Bétis Séville | 2-4a.Prlg | 2 - 4 points |
| CDR | 16/12/21 19:00 | 16/12/21 19:00 | CD Arenteiro | Valence CF | 1-3a.Prlg | 2 - 4 points |
| CDR | 16/12/21 20:00 | 16/12/21 20:00 | CD Lugo | CD Mirandes | 1-2 | 2 - 4 points |
| CDR | 16/12/21 21:00 | 16/12/21 21:00 | Albacete Balompie | FC Cadiz | 0-1 | 2 - 4 points |
| CDR | 16/12/21 21:00 | 16/12/21 21:00 | Atletico Baleares | FC Getafe | 5-0 | 2 - 4 points |
| CDR | 16/12/21 21:00 | 16/12/21 21:00 | Atletico Mancha Real | Granada CF | 1-0 | 2 - 4 points |
| CDR | 16/12/21 21:00 | 16/12/21 21:00 | Deportivo La Coruna | CA Osasuna | 1-2 | 2 - 4 points |