Calendrier
| Date | Clôture des pronostics | À domicile | A l'extérieur | Résultat | Règle des points |
|---|---|---|---|---|---|
| 25/09/21 17:00 | 25/09/21 17:00 | AS St. Etienne | OGC Nice | 0-3 | 2 - 4 points |
| 25/09/21 19:00 | 25/09/21 19:00 | Racing Club Strasbourg | LOSC Lille | 1-2 | 2 - 4 points |
| 25/09/21 21:00 | 25/09/21 21:00 | Olympique Lyonnais | FC Lorient | 1-1 | 2 - 4 points |
| 25/09/21 21:00 | 25/09/21 21:00 | Paris Saint-Germain | Montpellier Hérault SC | 2-0 | 2 - 4 points |
| 26/09/21 13:00 | 26/09/21 13:00 | Girondins de Bordeaux | Stade Rennais FC | 1-1 | 2 - 4 points |
| 26/09/21 15:00 | 26/09/21 15:00 | ES Troyes AC | Angers SCO | 1-1 | 2 - 4 points |
| 26/09/21 15:00 | 26/09/21 15:00 | Stade Brestois 29 | FC Metz | 1-2 | 2 - 4 points |
| 26/09/21 15:00 | 26/09/21 15:00 | Stade de Reims | FC Nantes | 3-1 | 2 - 4 points |
| 26/09/21 17:05 | 26/09/21 17:05 | Clermont Foot | AS Monaco | 1-3 | 2 - 4 points |
| 26/09/21 20:45 | 26/09/21 20:45 | Olympique de Marseille | RC Lens | 2-3 | 2 - 4 points |