Calendrier
| Date | Clôture des pronostics | À domicile | A l'extérieur | Résultat | Règle des points |
|---|---|---|---|---|---|
| 22/09/21 19:00 | 22/09/21 19:00 | FC Nantes | Stade Brestois 29 | 3-1 | 2 - 4 points |
| 22/09/21 19:00 | 22/09/21 19:00 | Stade Rennais FC | Clermont Foot | 6-0 | 2 - 4 points |
| 22/09/21 19:00 | 22/09/21 19:00 | LOSC Lille | Stade de Reims | 2-1 | 2 - 4 points |
| 22/09/21 19:00 | 22/09/21 19:00 | AS Monaco | AS St. Etienne | 3-1 | 2 - 4 points |
| 22/09/21 19:00 | 22/09/21 19:00 | Montpellier Hérault SC | Girondins de Bordeaux | 3-3 | 2 - 4 points |
| 22/09/21 21:00 | 22/09/21 21:00 | Angers SCO | Olympique de Marseille | 0-0 | 2 - 4 points |
| 22/09/21 21:00 | 22/09/21 21:00 | RC Lens | Racing Club Strasbourg | 0-1 | 2 - 4 points |
| 22/09/21 21:00 | 22/09/21 21:00 | FC Lorient | OGC Nice | 1-0 | 2 - 4 points |
| 22/09/21 21:00 | 22/09/21 21:00 | Olympique Lyonnais | ES Troyes AC | 3-1 | 2 - 4 points |
| 22/09/21 21:00 | 22/09/21 21:00 | FC Metz | Paris Saint-Germain | 1-2 | 2 - 4 points |