Calendrier
| Date | Clôture des pronostics | À domicile | A l'extérieur | Résultat | Règle des points |
|---|---|---|---|---|---|
| 10/12/21 21:00 | 10/12/21 21:00 | FC Nantes | RC Lens | 3-2 | 2 - 4 points |
| 11/12/21 17:00 | 11/12/21 17:00 | Stade Brestois 29 | Montpellier Hérault SC | 0-4 | 2 - 4 points |
| 11/12/21 21:00 | 11/12/21 21:00 | Stade de Reims | AS St. Etienne | 2-0 | 2 - 4 points |
| 12/12/21 13:00 | 12/12/21 13:00 | LOSC Lille | Olympique Lyonnais | 0-0 | 2 - 4 points |
| 12/12/21 15:00 | 12/12/21 15:00 | Angers SCO | Clermont Foot | 0-1 | 2 - 4 points |
| 12/12/21 15:00 | 12/12/21 15:00 | FC Metz | FC Lorient | 4-1 | 2 - 4 points |
| 12/12/21 15:00 | 12/12/21 15:00 | Stade Rennais FC | OGC Nice | 1-2 | 2 - 4 points |
| 12/12/21 15:00 | 12/12/21 15:00 | ES Troyes AC | Girondins de Bordeaux | 1-2 | 2 - 4 points |
| 12/12/21 17:05 | 12/12/21 17:05 | Racing Club Strasbourg | Olympique de Marseille | 0-2 | 2 - 4 points |
| 12/12/21 20:45 | 12/12/21 20:45 | Paris Saint-Germain | AS Monaco | 2-0 | 2 - 4 points |