| Date | À domicile | A l'extérieur | Résultat |
|---|---|---|---|
| 28/10/22 02:15 | Tampa Bay Buccaneers | Baltimore Ravens | 22-27 |
| 30/10/22 14:30 | Jacksonville Jaguars | Denver Broncos | 17-21 |
| 30/10/22 18:00 | Dallas Cowboys | Chicago Bears | 49-29 |
| 30/10/22 18:00 | Atlanta Falcons | Carolina Panthers | 37-34OT |
| 30/10/22 18:00 | New York Jets | New England Patriots | 17-22 |
| 30/10/22 18:00 | Detroit Lions | Miami Dolphins | 27-31 |
| 30/10/22 18:00 | Philadelphia Eagles | Pittsburgh Steelers | 35-13 |
| 30/10/22 18:00 | New Orleans Saints | Las Vegas Raiders | 24-0 |
| 30/10/22 18:00 | Minnesota Vikings | Arizona Cardinals | 34-26 |
| 30/10/22 21:05 | Houston Texans | Tennessee Titans | 10-17 |
| 30/10/22 21:25 | Indianapolis Colts | Washington Commanders | 16-17 |
| 30/10/22 21:25 | Seattle Seahawks | New York Giants | 27-13 |
| 30/10/22 21:25 | Los Angeles Rams | San Francisco 49ers | 14-31 |
| 31/10/22 01:20 | Buffalo Bills | Green Bay Packers | 27-17 |
| 01/11/22 01:15 | Cleveland Browns | Cincinnati Bengals | 32-13 |