| Date | À domicile | A l'extérieur | Résultat |
|---|---|---|---|
| 14/10/22 02:15 | Chicago Bears | Washington Commanders | 7-12 |
| 16/10/22 19:00 | Pittsburgh Steelers | Tampa Bay Buccaneers | 20-18 |
| 16/10/22 19:00 | New Orleans Saints | Cincinnati Bengals | 26-30 |
| 16/10/22 19:00 | New York Giants | Baltimore Ravens | 24-20 |
| 16/10/22 19:00 | Green Bay Packers | New York Jets | 10-27 |
| 16/10/22 19:00 | Miami Dolphins | Minnesota Vikings | 16-24 |
| 16/10/22 19:00 | Indianapolis Colts | Jacksonville Jaguars | 34-27 |
| 16/10/22 19:00 | Atlanta Falcons | San Francisco 49ers | 28-14 |
| 16/10/22 19:00 | Cleveland Browns | New England Patriots | 15-38 |
| 16/10/22 22:05 | Seattle Seahawks | Arizona Cardinals | 19-9 |
| 16/10/22 22:05 | Los Angeles Rams | Carolina Panthers | 24-10 |
| 16/10/22 22:25 | Kansas City Chiefs | Buffalo Bills | 20-24 |
| 17/10/22 02:20 | Philadelphia Eagles | Dallas Cowboys | 26-17 |
| 18/10/22 02:15 | Los Angeles Chargers | Denver Broncos | 19-16OT |