| Date | À domicile | A l'extérieur | Résultat |
|---|---|---|---|
| 23/09/22 02:15 | Cleveland Browns | Pittsburgh Steelers | 29-17 |
| 25/09/22 19:00 | Washington Commanders | Philadelphia Eagles | 8-24 |
| 25/09/22 19:00 | Tennessee Titans | Las Vegas Raiders | 24-22 |
| 25/09/22 19:00 | New England Patriots | Baltimore Ravens | 26-37 |
| 25/09/22 19:00 | New York Jets | Cincinnati Bengals | 12-27 |
| 25/09/22 19:00 | Carolina Panthers | New Orleans Saints | 22-14 |
| 25/09/22 19:00 | Minnesota Vikings | Detroit Lions | 28-24 |
| 25/09/22 19:00 | Miami Dolphins | Buffalo Bills | 21-19 |
| 25/09/22 19:00 | Indianapolis Colts | Kansas City Chiefs | 20-17 |
| 25/09/22 19:00 | Chicago Bears | Houston Texans | 23-20 |
| 25/09/22 22:05 | Los Angeles Chargers | Jacksonville Jaguars | 10-38 |
| 25/09/22 22:25 | Tampa Bay Buccaneers | Green Bay Packers | 12-14 |
| 25/09/22 22:25 | Seattle Seahawks | Atlanta Falcons | 23-27 |
| 25/09/22 22:25 | Arizona Cardinals | Los Angeles Rams | 12-20 |
| 26/09/22 02:20 | Denver Broncos | San Francisco 49ers | 11-10 |
| 27/09/22 02:15 | New York Giants | Dallas Cowboys | 16-23 |