| Date | À domicile | A l'extérieur | Résultat |
|---|---|---|---|
| 16/09/22 02:15 | Kansas City Chiefs | Los Angeles Chargers | 27-24 |
| 18/09/22 19:00 | New York Giants | Carolina Panthers | 19-16 |
| 18/09/22 19:00 | Jacksonville Jaguars | Indianapolis Colts | 24-0 |
| 18/09/22 19:00 | Cleveland Browns | New York Jets | 30-31 |
| 18/09/22 19:00 | Detroit Lions | Washington Commanders | 36-27 |
| 18/09/22 19:00 | New Orleans Saints | Tampa Bay Buccaneers | 10-20 |
| 18/09/22 19:00 | Pittsburgh Steelers | New England Patriots | 14-17 |
| 18/09/22 19:00 | Baltimore Ravens | Miami Dolphins | 38-42 |
| 18/09/22 22:05 | San Francisco 49ers | Seattle Seahawks | 27-7 |
| 18/09/22 22:05 | Los Angeles Rams | Atlanta Falcons | 31-27 |
| 18/09/22 22:25 | Dallas Cowboys | Cincinnati Bengals | 20-17 |
| 18/09/22 22:25 | Denver Broncos | Houston Texans | 16-9 |
| 18/09/22 22:25 | Las Vegas Raiders | Arizona Cardinals | 23-29OT |
| 19/09/22 02:20 | Green Bay Packers | Chicago Bears | 27-10 |
| 20/09/22 01:15 | Buffalo Bills | Tennessee Titans | 41-7 |
| 20/09/22 02:30 | Philadelphia Eagles | Minnesota Vikings | 24-7 |