| Date | À domicile | A l'extérieur | Résultat |
|---|---|---|---|
| 09/09/22 02:20 | Los Angeles Rams | Buffalo Bills | 10-31 |
| 11/09/22 19:00 | Miami Dolphins | New England Patriots | 20-7 |
| 11/09/22 19:00 | Houston Texans | Indianapolis Colts | 20-20OT |
| 11/09/22 19:00 | New York Jets | Baltimore Ravens | 9-24 |
| 11/09/22 19:00 | Detroit Lions | Philadelphia Eagles | 35-38 |
| 11/09/22 19:00 | Cincinnati Bengals | Pittsburgh Steelers | 20-23OT |
| 11/09/22 19:00 | Carolina Panthers | Cleveland Browns | 24-26 |
| 11/09/22 19:00 | Chicago Bears | San Francisco 49ers | 19-10 |
| 11/09/22 19:00 | Washington Commanders | Jacksonville Jaguars | 28-22 |
| 11/09/22 19:00 | Atlanta Falcons | New Orleans Saints | 26-27 |
| 11/09/22 22:25 | Minnesota Vikings | Green Bay Packers | 23-7 |
| 11/09/22 22:25 | Arizona Cardinals | Kansas City Chiefs | 21-44 |
| 11/09/22 22:25 | Tennessee Titans | New York Giants | 20-21 |
| 11/09/22 22:25 | Los Angeles Chargers | Las Vegas Raiders | 24-19 |
| 12/09/22 02:20 | Dallas Cowboys | Tampa Bay Buccaneers | 3-19 |
| 13/09/22 02:15 | Seattle Seahawks | Denver Broncos | 17-16 |