| Date | À domicile | A l'extérieur | Résultat |
|---|---|---|---|
| 23/04/23 01:30 | New York City FC | FC Dallas | 3-1 |
| 23/04/23 01:30 | Orlando City | D.C. United | 1-3 |
| 23/04/23 01:30 | Cincinnati FC | Portland Timbers | 2-1 |
| 23/04/23 01:30 | New England Revolution | Sporting Kansas City | 2-1 |
| 23/04/23 01:30 | Charlotte FC | Columbus Crew | 1-0 |
| 23/04/23 01:30 | CF Montreal | New York Red Bulls | 2-0 |
| 23/04/23 01:30 | Philadelphia Union | Toronto FC | 4-2 |
| 23/04/23 02:30 | Houston Dynamo | Inter Miami CF | 1-0 |
| 23/04/23 02:30 | Nashville SC | Los Angeles FC | 1-1 |
| 23/04/23 03:30 | Real Salt Lake | San Jose Earthquakes | 3-1 |
| 23/04/23 03:30 | Colorado Rapids | St. Louis City SC | 1-1 |
| 23/04/23 04:30 | Los Angeles Galaxy | Austin FC | 2-0 |
| 23/04/23 04:30 | Seattle Sounders | Minnesota United FC | 1-0 |
| 23/04/23 22:30 | Atlanta United FC | Chicago Fire | 2-1 |