| Date | À domicile | A l'extérieur | Résultat |
|---|---|---|---|
| 06/11/25 18:45 | FC Utrecht | FC Porto | 1-1 |
| 06/11/25 18:45 | Red Bull Salzbourg | Go Ahead Eagles Deventer | 2-0 |
| 06/11/25 18:45 | Etoile Rouge Belgrade | LOSC Lille | 1-0 |
| 06/11/25 18:45 | SK Sturm Graz | Nottingham Forest | 0-0 |
| 06/11/25 18:45 | FC Midtjylland | Celtic Glasgow | 3-1 |
| 06/11/25 18:45 | FC Basel | FCSB Bukarest | 3-1 |
| 06/11/25 18:45 | Dinamo Zagreb | Celta Vigo | 0-3 |
| 06/11/25 18:45 | Malmö FF | Panathinaikos Athènes | 0-1 |
| 06/11/25 18:45 | OGC Nice | SC Freiburg | 1-3 |
| 06/11/25 21:00 | FC Bologna | Brann Bergen | 0-0 |
| 06/11/25 21:00 | Sporting Braga | KRC Genk | 3-4 |
| 06/11/25 21:00 | PAOK Saloniki | Young Boys Bern | 4-0 |
| 06/11/25 21:00 | Aston Villa | Maccabi Tel Aviv | 2-0 |
| 06/11/25 21:00 | VfB Stuttgart | Feyenoord Rotterdam | 2-0 |
| 06/11/25 21:00 | Ferencvaros Budapest | PFC Ludogorets Razgrad | 3-1 |
| 06/11/25 21:00 | Glasgow Rangers | AS Rome | 0-2 |
| 06/11/25 21:00 | Bétis Séville | Olympique Lyonnais | 2-0 |
| 06/11/25 21:00 | Viktoria Plzen | Fenerbahce Istanbul | 0-0 |