| Date | À domicile | A l'extérieur | Résultat |
|---|---|---|---|
| 02/10/25 18:45 | FC Bologna | SC Freiburg | 1-1 |
| 02/10/25 18:45 | FCSB Bukarest | Young Boys Bern | 0-2 |
| 02/10/25 18:45 | Viktoria Plzen | Malmö FF | 3-0 |
| 02/10/25 18:45 | Celtic Glasgow | Sporting Braga | 0-2 |
| 02/10/25 18:45 | Panathinaikos Athènes | Go Ahead Eagles Deventer | 1-2 |
| 02/10/25 18:45 | Fenerbahce Istanbul | OGC Nice | 2-1 |
| 02/10/25 18:45 | AS Rome | LOSC Lille | 0-1 |
| 02/10/25 18:45 | Brann Bergen | FC Utrecht | 1-0 |
| 02/10/25 18:45 | PFC Ludogorets Razgrad | Bétis Séville | 0-2 |
| 02/10/25 21:00 | Feyenoord Rotterdam | Aston Villa | 0-2 |
| 02/10/25 21:00 | FC Porto | Etoile Rouge Belgrade | 2-1 |
| 02/10/25 21:00 | FC Basel | VfB Stuttgart | 2-0 |
| 02/10/25 21:00 | Olympique Lyonnais | Red Bull Salzbourg | 2-0 |
| 02/10/25 21:00 | KRC Genk | Ferencvaros Budapest | 0-1 |
| 02/10/25 21:00 | Maccabi Tel Aviv | Dinamo Zagreb | 1-3 |
| 02/10/25 21:00 | Nottingham Forest | FC Midtjylland | 2-3 |
| 02/10/25 21:00 | SK Sturm Graz | Glasgow Rangers | 2-1 |
| 02/10/25 21:00 | Celta Vigo | PAOK Saloniki | 3-1 |