| Date | À domicile | A l'extérieur | Résultat |
|---|---|---|---|
| 18/12/25 21:00 | FC Lausanne-Sport | AC Florenz | 1-0 |
| 18/12/25 21:00 | AZ Alkmaar | Jagiellonia Bialystok | 0-0 |
| 18/12/25 21:00 | Shakhtar Donetsk | HNK Rijeka | 0-0 |
| 18/12/25 21:00 | SK Slovan Bratislava | BK Häcken | 1-0 |
| 18/12/25 21:00 | Legia Warschau | Lincoln Red Imps FC | 4-1 |
| 18/12/25 21:00 | Sparta Prag | FC Aberdeen | 3-0 |
| 18/12/25 21:00 | Dynamo Kiew | FC Noah | 2-0 |
| 18/12/25 21:00 | Crystal Palace | Kuopion PS | 2-2 |
| 18/12/25 21:00 | Rayo Vallecano | KF Drita Gjilan | 3-0 |
| 18/12/25 21:00 | Shamrock Rovers | Hamrun Spartans | 3-1 |
| 18/12/25 21:00 | Omonia Nicosia | KS Rakow Czestochowa | 0-1 |
| 18/12/25 21:00 | FSV Mayence 05 | Samsunspor | 2-0 |
| 18/12/25 21:00 | Racing Club Strasbourg | Breidablik Kopavogur | 3-1 |
| 18/12/25 21:00 | NK Celje | FC Shelbourne | 0-0 |
| 18/12/25 21:00 | HŠK Zrinjski Mostar | SK Rapid Wien | 1-1 |
| 18/12/25 21:00 | AEK Athènes | Universitatea Craiova | 3-2 |
| 18/12/25 21:00 | Sigma Olomouc | Lech Poznan | 1-2 |
| 18/12/25 21:00 | AEK Larnaka | KF Shkendija | 1-0 |