Calendrier
| Date | Clôture des pronostics | À domicile | A l'extérieur | Résultat | Règle des points |
|---|---|---|---|---|---|
| 25/09/21 15:00 | 25/09/21 15:00 | Spezia Calcio | AC Milan | 1-2 | 2 - 5 points |
| 25/09/21 18:00 | 25/09/21 18:00 | Inter Milan | Atalanta Bergamo | 2-2 | 2 - 5 points |
| 25/09/21 20:45 | 25/09/21 20:45 | FC Genua 1893 | Hellas Verona | 3-3 | 2 - 5 points |
| 26/09/21 12:30 | 26/09/21 12:30 | Juventus Turin | Sampdoria Genua | 3-2 | 2 - 5 points |
| 26/09/21 15:00 | 26/09/21 15:00 | FC Empoli | FC Bologna | 4-2 | 2 - 5 points |
| 26/09/21 15:00 | 26/09/21 15:00 | Udinese Calcio | AC Florenz | 0-1 | 2 - 5 points |
| 26/09/21 15:00 | 26/09/21 15:00 | Sassuolo Calcio | US Salernitana | 1-0 | 2 - 5 points |
| 26/09/21 18:00 | 26/09/21 18:00 | Lazio Rom | AS Rome | 3-2 | 2 - 5 points |
| 26/09/21 20:45 | 26/09/21 20:45 | SSC Naples | Cagliari Calcio | 2-0 | 2 - 5 points |
| 27/09/21 20:45 | 27/09/21 20:45 | FC Venise | FC Turin | 1-1 | 2 - 5 points |