Calendrier
| Date | Clôture des pronostics | À domicile | A l'extérieur | Résultat | Règle des points |
|---|---|---|---|---|---|
| 11/09/21 15:00 | 11/09/21 15:00 | FC Empoli | FC Venise | 1-2 | 2 - 5 points |
| 11/09/21 18:00 | 11/09/21 18:00 | SSC Naples | Juventus Turin | 2-1 | 2 - 5 points |
| 11/09/21 20:45 | 11/09/21 20:45 | Atalanta Bergamo | AC Florenz | 1-2 | 2 - 5 points |
| 12/09/21 12:30 | 12/09/21 12:30 | Sampdoria Genua | Inter Milan | 2-2 | 2 - 5 points |
| 12/09/21 15:00 | 12/09/21 15:00 | FC Turin | US Salernitana | 4-0 | 2 - 5 points |
| 12/09/21 15:00 | 12/09/21 15:00 | Cagliari Calcio | FC Genua 1893 | 2-3 | 2 - 5 points |
| 12/09/21 15:00 | 12/09/21 15:00 | Spezia Calcio | Udinese Calcio | 0-1 | 2 - 5 points |
| 12/09/21 18:00 | 12/09/21 18:00 | AC Milan | Lazio Rom | 2-0 | 2 - 5 points |
| 12/09/21 20:45 | 12/09/21 20:45 | AS Rome | Sassuolo Calcio | 2-1 | 2 - 5 points |
| 13/09/21 20:45 | 13/09/21 20:45 | FC Bologna | Hellas Verona | 1-0 | 2 - 5 points |