Calendrier
| Date | Clôture des pronostics | À domicile | A l'extérieur | Résultat | Règle des points |
|---|---|---|---|---|---|
| 16/10/21 13:30 | 16/10/21 13:30 | FC Watford | FC Liverpool | 0-5 | 2 - 5 points |
| 16/10/21 16:00 | 16/10/21 16:00 | Aston Villa | Wolverhampton Wanderers | 2-3 | 2 - 5 points |
| 16/10/21 16:00 | 16/10/21 16:00 | Leicester City | Manchester United | 4-2 | 2 - 5 points |
| 16/10/21 16:00 | 16/10/21 16:00 | Manchester City | FC Burnley | 2-0 | 2 - 5 points |
| 16/10/21 16:00 | 16/10/21 16:00 | Norwich City | Brighton and Hove Albion | 0-0 | 2 - 5 points |
| 16/10/21 16:00 | 16/10/21 16:00 | FC Southampton | Leeds United | 1-0 | 2 - 5 points |
| 16/10/21 18:30 | 16/10/21 18:30 | Brentford FC | FC Chelsea | 0-1 | 2 - 5 points |
| 17/10/21 15:00 | 17/10/21 15:00 | FC Everton | West Ham United | 0-1 | 2 - 5 points |
| 17/10/21 17:30 | 17/10/21 17:30 | Newcastle United | Tottenham Hotspur | 2-3 | 2 - 5 points |
| 18/10/21 21:00 | 18/10/21 21:00 | FC Arsenal | Crystal Palace | 2-2 | 2 - 5 points |