Calendrier
| Date | Clôture des pronostics | À domicile | A l'extérieur | Résultat | Règle des points |
|---|---|---|---|---|---|
| 25/09/21 13:30 | 25/09/21 13:30 | Manchester United | Aston Villa | 0-1 | 2 - 5 points |
| 25/09/21 13:30 | 25/09/21 13:30 | FC Chelsea | Manchester City | 0-1 | 2 - 5 points |
| 25/09/21 16:00 | 25/09/21 16:00 | Leeds United | West Ham United | 1-2 | 2 - 5 points |
| 25/09/21 16:00 | 25/09/21 16:00 | Leicester City | FC Burnley | 2-2 | 2 - 5 points |
| 25/09/21 16:00 | 25/09/21 16:00 | FC Watford | Newcastle United | 1-1 | 2 - 5 points |
| 25/09/21 16:00 | 25/09/21 16:00 | FC Everton | Norwich City | 2-0 | 2 - 5 points |
| 25/09/21 18:30 | 25/09/21 18:30 | Brentford FC | FC Liverpool | 3-3 | 2 - 5 points |
| 26/09/21 15:00 | 26/09/21 15:00 | FC Southampton | Wolverhampton Wanderers | 0-1 | 2 - 5 points |
| 26/09/21 17:30 | 26/09/21 17:30 | FC Arsenal | Tottenham Hotspur | 3-1 | 2 - 5 points |
| 27/09/21 21:00 | 27/09/21 21:00 | Crystal Palace | Brighton and Hove Albion | 1-1 | 2 - 5 points |