Calendrier
| Date | Clôture des pronostics | À domicile | A l'extérieur | Résultat | Règle des points |
|---|---|---|---|---|---|
| 11/09/21 13:30 | 11/09/21 13:30 | Crystal Palace | Tottenham Hotspur | 3-0 | 2 - 5 points |
| 11/09/21 16:00 | 11/09/21 16:00 | Brentford FC | Brighton and Hove Albion | 0-1 | 2 - 5 points |
| 11/09/21 16:00 | 11/09/21 16:00 | Leicester City | Manchester City | 0-1 | 2 - 5 points |
| 11/09/21 16:00 | 11/09/21 16:00 | Manchester United | Newcastle United | 4-1 | 2 - 5 points |
| 11/09/21 16:00 | 11/09/21 16:00 | FC Southampton | West Ham United | 0-0 | 2 - 5 points |
| 11/09/21 16:00 | 11/09/21 16:00 | FC Arsenal | Norwich City | 1-0 | 2 - 5 points |
| 11/09/21 16:00 | 11/09/21 16:00 | FC Watford | Wolverhampton Wanderers | 0-2 | 2 - 5 points |
| 11/09/21 18:30 | 11/09/21 18:30 | FC Chelsea | Aston Villa | 3-0 | 2 - 5 points |
| 12/09/21 17:30 | 12/09/21 17:30 | Leeds United | FC Liverpool | 0-3 | 2 - 5 points |
| 13/09/21 21:00 | 13/09/21 21:00 | FC Everton | FC Burnley | 3-1 | 2 - 5 points |