Calendrier
| Date | Clôture des pronostics | À domicile | A l'extérieur | Résultat | Règle des points |
|---|---|---|---|---|---|
| 05/11/21 21:00 | 05/11/21 21:00 | FC Southampton | Aston Villa | 1-0 | 2 - 5 points |
| 06/11/21 13:30 | 06/11/21 13:30 | Manchester United | Manchester City | 0-2 | 2 - 5 points |
| 06/11/21 16:00 | 06/11/21 16:00 | Brentford FC | Norwich City | 1-2 | 2 - 5 points |
| 06/11/21 16:00 | 06/11/21 16:00 | FC Chelsea | FC Burnley | 1-1 | 2 - 5 points |
| 06/11/21 16:00 | 06/11/21 16:00 | Crystal Palace | Wolverhampton Wanderers | 2-0 | 2 - 5 points |
| 06/11/21 18:30 | 06/11/21 18:30 | Brighton and Hove Albion | Newcastle United | 1-1 | 2 - 5 points |
| 07/11/21 15:00 | 07/11/21 15:00 | FC Arsenal | FC Watford | 1-0 | 2 - 5 points |
| 07/11/21 15:00 | 07/11/21 15:00 | FC Everton | Tottenham Hotspur | 0-0 | 2 - 5 points |
| 07/11/21 15:00 | 07/11/21 15:00 | Leeds United | Leicester City | 1-1 | 2 - 5 points |
| 07/11/21 17:30 | 07/11/21 17:30 | West Ham United | FC Liverpool | 3-2 | 2 - 5 points |